Bureau of Reclamation selects three submissions to receive prizes for the eradication of invasive mussels in open water prize competition

Media Contact: Peter Soeth, 303-445-3615, psoeth@usbr.gov

For Release: October 29, 2018

Invasive mussels in the Colorado River.
Invasive mussels in the Colorado River.
WASHINGTON - Bureau of Reclamation Commissioner Brenda Burman announced today that Reclamation has selected three submissions for its prize competition seeking ideas to eradicate mussels in open water. Steven Suhr and Marie-Claude Senut will receive a full award of $80,000 for their idea while Wen Chen and Absar Alum with Stephanie Bone will each receive $10,000.

"Providing water managers with new tools to control invasive quagga and zebra mussels is an important part of protecting infrastructure and ecosystems," Commissioner Burman said. "Reclamation is committed to working with our partners to prevent the spread of quagga and zebra mussels in the West."

The prize competition was a theoretical challenge and sought innovative solutions to eradicate invasive quagga and zebra mussels from large reservoirs, lakes and rivers in a cost-effective and environmentally sound manner. Invasive mussel infestations pose a significant logistical and economic challenge for local communities, recreationists and water managers. There is no practical method available today for the large-scale control of invasive dreissenid mussel population once they become established.

Steven Suhr and Marie-Claude Senut, founders of Biomilab, LLC, proposed using genomic modification to induce a lethal malignant hemic neoplasia in mussels that can be transferred from one mussel to another by proximity. They suggested utilizing the CRISPR/cas9-mediated genome modification to target the function or expression of endogenous dreissenid mussel p53 or telomerase reverse transcriptase genes, or to introduce the viral SV40 Tag gene. This submission for the prize competition received $80,000.

Wen Chen, a research scientist at Harvard Medical School, proposed utilizing single stranded DNA/RNA oligonucleotide-based aptamers to target the modified amino acid 3,4 dihydroxyphenylalanine (DOPA) or dreissenid specific foot proteins to interrupt attachment, eventually leading to mussel mortality. The use of aptamers to target DOPA and foot proteins to interrupt mussel settlement is a novel idea and received $10,000.

Absar Alum of BioDetek with Stephanie Bone proposed genome modification to develop male mussels that produce sperm containing a light triggered optogenetic switch to drive upregulation or downregulation of cyclin-b expression resulting in death of the fertilized egg. This strategy relies on sunlight penetration into the upper portions of a water body to turn on the optogenetic switch in free-floating, transparent developing eggs and embryos. It was found to be a novel idea and received $10,000.

A total of 238 solvers signed up to solve this challenge and more than 100 solvers submitted solutions. Of those solutions submitted, 67 were deemed viable and were judged. Reclamation collaborated with the U.S. Geological Survey, the U.S. Army Corps of Engineers, and Molloy & Associates on this prize competition. To learn more about this prize competition please visit https://www.usbr.gov/research/challenges/mussels.html.

The results of this prize competition will support a broader effort by the federal government, as well as work by the Western Governors' Association, western states, and tribes to protect western ecosystems, water infrastructure and hydroelectric facilities from invasive mussels. To learn more, please visit https://www.usbr.gov/mussels.

To learn more prize competitions at Reclamation, please visit Reclamation's Water Prize Competition Center at: www.usbr.gov/research/challenges/index.html.

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Reclamation is the largest wholesale water supplier in the United States, and the nation's second largest producer of hydroelectric power. Its facilities also provide substantial flood control, recreation, and fish and wildlife benefits. Visit our website at https://www.usbr.gov and follow us on Twitter @USBR.